The RNA binding proteins RBM38 and DND1 are repressed in AML and have a novel function in APL differentiation

Highlights • RBM38 and DND1 expression is attenuated in primary AML patients. • Normal and leukemic neutrophil differentiation induces RBM38 and DND1 expression. • New function for the RNA binding proteins RBM38 and DND1 in APL differentiation.

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Bibliographische Detailangaben
Veröffentlicht in:	Leukemia research 2016-02, Vol.41, p.96-102
Hauptverfasser:	Wampfler, Julian, Federzoni, Elena A, Torbett, Bruce E, Fey, Martin F, Tschan, Mario P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Acute promyelocytic leukemia Adolescent Adult Aged Blotting, Western Cell Differentiation DND1 Female Gene Expression Regulation, Leukemic - physiology Gene Knockdown Techniques Hematology, Oncology and Palliative Medicine Humans Leukemia, Myeloid, Acute - pathology Leukemia, Promyelocytic, Acute - pathology Male Middle Aged Neoplasm Proteins - biosynthesis Neutrophil differentiation Neutrophils - pathology RBM38 Real-Time Polymerase Chain Reaction RNA-Binding Proteins - biosynthesis Young Adult
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Beschreibung
Zusammenfassung:	Highlights • RBM38 and DND1 expression is attenuated in primary AML patients. • Normal and leukemic neutrophil differentiation induces RBM38 and DND1 expression. • New function for the RNA binding proteins RBM38 and DND1 in APL differentiation.
ISSN:	0145-2126 1873-5835
DOI:	10.1016/j.leukres.2015.12.006