No evidence of asymptomatic variant CJD infection in immunodeficiency patients treated with UK-sourced immunoglobulin

Surveillance of 75 immunodeficiency patients exposed to UK‐sourced immunoglobulin, including batches derived from donors who went on to develop vCJD, has not detected any clinical cases of vCJD, or of asymptomatic infection in 15 patients with available tissue samples of sufficient quality for testi...

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Veröffentlicht in:	Vox sanguinis 2016-04, Vol.110 (3), p.282-284
Hauptverfasser:	Helbert, M. R., Bangs, C., Bishop, M., Molesworth, A., Ironside, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Asymptomatic Infections Blood & organ donations Blood Donors Creutzfeldt-Jakob Syndrome - transmission Genotype Hematology Humans Immunoglobulins Immunoglobulins, Intravenous - administration & dosage Immunologic Deficiency Syndromes - drug therapy Immunologic Deficiency Syndromes - pathology Polymorphism, Genetic Prion Proteins - genetics prions
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Beschreibung
Zusammenfassung:	Surveillance of 75 immunodeficiency patients exposed to UK‐sourced immunoglobulin, including batches derived from donors who went on to develop vCJD, has not detected any clinical cases of vCJD, or of asymptomatic infection in 15 patients with available tissue samples of sufficient quality for testing.
ISSN:	0042-9007 1423-0410
DOI:	10.1111/vox.12358