Diphenyl Diselenide Protects Against Mortality, Locomotor Deficits and Oxidative Stress in Drosophila melanogaster Model of Manganese-Induced Neurotoxicity

Several experimental and epidemiological reports have associated manganese exposure with induction of oxidative stress and locomotor dysfunctions. Diphenyl diselenide (DPDS) is widely reported to exhibit antioxidant, anti-inflammatory and neuroprotective effects in in vitro and in vivo studies via m...

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Veröffentlicht in:	Neurochemical research 2016-06, Vol.41 (6), p.1430-1438
Hauptverfasser:	Adedara, Isaac A., Abolaji, Amos O., Rocha, Joao B. T., Farombi, Ebenezer O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Benzene Derivatives - pharmacology Benzene Derivatives - therapeutic use Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Disease Models, Animal Drosophila melanogaster Manganese - toxicity Mortality - trends Neurochemistry Neurology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosciences Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - mortality Neurotoxicity Syndromes - prevention & control Organoselenium Compounds - pharmacology Organoselenium Compounds - therapeutic use Original Paper Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Tabes Dorsalis - metabolism Tabes Dorsalis - mortality Tabes Dorsalis - prevention & control
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