Neurotoxic and myotoxic actions of crotoxin-like and Crotalus durissus cascavella whole venom in the chick biventer cervicis preparation

Neurotoxic and myotoxic actions of crotoxin-like and Crotalus durissus cascavella whole venom in the chick biventer cervicis preparation

Crotoxin from Crotalus durissus cascavella venom was purified by a combination of molecular exclusion chromatography (Superdex 75 column) and HPLC molecular exclusion (Protein Pack 300SW column). Neurotoxic and myotoxic effects from C. durissus cascavella whole venom and its main fraction, the croto...

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Veröffentlicht in:Toxicon (Oxford) 2004-03, Vol.43 (3), p.255-261
Hauptverfasser: Beghini, Daniela G, Rodrigues-Simioni, Léa, Toyama, M.H, Novello, J.C, da Cruz-Höfling, Maria Alice, Marangoni, S
Format: Artikel
Sprache:eng
Schlagworte:
Acetylcholine
Animal poisons toxicology. Antivenoms
Animals
Biological and medical sciences
Chickens
Crotalid Venoms - toxicity
Crotalus durissus cascavella
Dose-Response Relationship, Drug
KCl
Male
Medical sciences
Muscle Contraction - drug effects
Muscle, Skeletal - drug effects
Muscle, Skeletal - innervation
Myotoxicity
Neuromuscular blockade
Neuromuscular Junction - drug effects
Neurotoxicity
Neurotoxins - toxicity
Toxicology
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Zusammenfassung:Crotoxin from Crotalus durissus cascavella venom was purified by a combination of molecular exclusion chromatography (Superdex 75 column) and HPLC molecular exclusion (Protein Pack 300SW column). Neurotoxic and myotoxic effects from C. durissus cascavella whole venom and its main fraction, the crotoxin-like, were studied in the chick biventer cervicis (CBC) nerve–muscle preparation. Both venom and its crotoxin showed significant ( p
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2003.12.001