Detection of amino acid substitutions in the GyrA protein of fluoroquinolone-resistant typhoidal Salmonella isolates using high-resolution mass spectrometry

Highlights • A LC–MS methodology was developed to identify fluoroquinolone-resistant Salmonella. • Reliable and rapid detection of fluoroquinolone resistance is feasible using LC–MS. • LC–MS can be a useful tool in future detection of antibiotic resistance.

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Bibliographische Detailangaben
Veröffentlicht in:	International journal of antimicrobial agents 2016-05, Vol.47 (5), p.351-356
Hauptverfasser:	Hassing, Robert-Jan, Goessens, Wil H, Zeneyedpour, Lona, Sultan, Sadaf, van Kampen, Jeroen J, Verbon, Annelies, van Genderen, Perry J, Hays, John P, Luider, Theo M, Dekker, Lennard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Anti-Bacterial Agents - pharmacology Antimicrobial resistance Chromatography, Liquid DNA Gyrase - analysis Fluoroquinolone Fluoroquinolones - pharmacology Humans Infectious Disease Mass spectrometry Mass Spectrometry - methods Mutant Proteins - analysis Salmonella Salmonella typhi - chemistry Salmonella typhi - drug effects Salmonella typhi - isolation & purification Time Factors
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Beschreibung
Zusammenfassung:	Highlights • A LC–MS methodology was developed to identify fluoroquinolone-resistant Salmonella. • Reliable and rapid detection of fluoroquinolone resistance is feasible using LC–MS. • LC–MS can be a useful tool in future detection of antibiotic resistance.
ISSN:	0924-8579 1872-7913
DOI:	10.1016/j.ijantimicag.2016.01.018