Randomized Trial of a Lifestyle Program in Obese Infertile Women

In this randomized trial, rates of vaginal birth of a healthy singleton at 2 years of follow-up were not higher among obese women who received a 6-month lifestyle intervention before infertility treatment than among those who received prompt infertility treatment. Obesity is a major public health problem. 1 In most developed countries, 14 to 20% of women of reproductive age are obese (body-mass index [BMI; the weight in kilograms divided by the square of the height in meters], ≥30), whereas in some countries, the prevalence of obesity is as high as 60%. 1 Obesity negatively affects female reproductive health because it is associated with increased risks of menstrual dysfunction, anovulation, and infertility. 2 – 4 Success rates with ovulation induction and assisted reproductive techniques are lower among obese infertile women than among normal-weight women. 5 , 6 The risks of miscarriage, 6 , 7 gestational diabetes, hypertensive disorders, . . .