Vitamin D and Lung Function Decline in Adults With Asthma: The HUNT Study

We investigated whether low 25-hydroxyvitamin D (25(OH)D) levels were associated with more lung function decline in adults with asthma and whether this association was modified by smoking status or inhaled corticosteroid (ICS) use. We analyzed data on 395 adults with asthma from the Nord-Trøndelag H...

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Veröffentlicht in:	American journal of epidemiology 2016-04, Vol.183 (8), p.739-746
Hauptverfasser:	Brumpton, Ben Michael, Langhammer, Arnulf, Henriksen, Anne Hildur, Camargo, Jr, Carlos Arturo, Chen, Yue, Romundstad, Pål Richard, Mai, Xiao-Mei
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adrenal Cortex Hormones - administration & dosage Adrenal Cortex Hormones - therapeutic use Adult Asthma Asthma - blood Asthma - physiopathology Correlation analysis Disease Progression Female Forced Expiratory Volume - physiology Health Surveys Humans Linear Models Lung - drug effects Lung - physiopathology Male Norway Plasma Prospective Studies Smoking - adverse effects Spirometry Vital Capacity - physiology Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D - physiology
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Zusammenfassung:	We investigated whether low 25-hydroxyvitamin D (25(OH)D) levels were associated with more lung function decline in adults with asthma and whether this association was modified by smoking status or inhaled corticosteroid (ICS) use. We analyzed data on 395 adults with asthma from the Nord-Trøndelag Health Study (1995-2008), Norway. Plasma 25(OH)D and lung function were measured at baseline, and lung function measurements were repeated at follow-up, approximately 11 years later. Linear regression was used to estimate lung function decline. Participants with low 25(OH)D (
ISSN:	0002-9262 1476-6256
DOI:	10.1093/aje/kwv243