Follicle-stimulating hormone promotes the growth of human epithelial ovarian cancer cells through the protein kinase C-mediated system

We have previously described that follicle-stimulating hormone (FSH) stimulated the growth of human epithelial ovarian cancer tissues and cells. In order to determine the signaling pathway on FSH action in ovarian cancer, we used an epithelial ovarian cancer cell line (HRA line) which constitutively...

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Veröffentlicht in:	Cancer letters 2001-05, Vol.166 (2), p.207-213
Hauptverfasser:	Ohtani, Kaori, Sakamoto, Hideki, Kikuchi, Atushi, Nakayama, Yasuo, Idei, Tomoko, Igarashi, Norie, Matukawa, Takahisa, Satoh, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Cell Division - drug effects Cell Line Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Epithelial Cells - drug effects Epithelial Cells - pathology Female Follicle Stimulating Hormone - pharmacology Follicle-stimulating hormone Fundamental and applied biological sciences. Psychology Human epithelial ovarian cancer cells Humans Isoenzymes - physiology Molecular and cellular biology Ovarian Neoplasms - pathology Protein kinase C Protein Kinase C - antagonists & inhibitors Protein Kinase C - physiology Staurosporine - pharmacology Tetradecanoylphorbol Acetate - pharmacology Thymidine
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Zusammenfassung:	We have previously described that follicle-stimulating hormone (FSH) stimulated the growth of human epithelial ovarian cancer tissues and cells. In order to determine the signaling pathway on FSH action in ovarian cancer, we used an epithelial ovarian cancer cell line (HRA line) which constitutively FSH receptors (FSHRs). FSH significantly increased cell proliferation (230.1±20.5%, P
ISSN:	0304-3835 1872-7980
DOI:	10.1016/S0304-3835(00)00713-8