Differential effects of somatostatin on exploratory behavior after unilateral injections into rat neostriatum

Differential effects of somatostatin on exploratory behavior after unilateral injections into rat neostriatum

The effects of somatostatin (SRIF) microinjected unilaterally (left or right) at a dose of 10, 50, and 100 ng into the neostriatum of male Wistar rats on exploratory behavior were studied. Unilateral injections of SRIF suppressed dose-related the exploratory activity as decreased the number of horiz...

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Veröffentlicht in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 2004, Vol.25 (1), p.123-128
Hauptverfasser: Tashev, Roman, Belcheva, Stiliana, Belcheva, Iren
Format: Artikel
Sprache:eng
Schlagworte:
Asymmetry
Biological and medical sciences
Exploratory behavior
Fundamental and applied biological sciences. Psychology
Neostriatum
Rat
Somatostatin
Vertebrates: endocrinology
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Zusammenfassung:The effects of somatostatin (SRIF) microinjected unilaterally (left or right) at a dose of 10, 50, and 100 ng into the neostriatum of male Wistar rats on exploratory behavior were studied. Unilateral injections of SRIF suppressed dose-related the exploratory activity as decreased the number of horizontal and vertical movements compared to the respective controls. The effect was more pronounced when SRIF was microinjected into the right neostriatum as compared to the left neostriatum. These findings suggest some asymmetric effects of SRIF, depending on the dose and the microinjected hemisphere.
ISSN:0196-9781
1873-5169
DOI:10.1016/j.peptides.2003.11.004