Myo1g is an active player in maintaining cell stiffness in B-lymphocytes

B‐lymphocytes are migrating cells that specialize in antigen presentation, antibody secretion, and endocytosis; these processes implicate the modulation of plasma membrane elasticity. Cell stiffness is a force generated by the interaction between the actin‐cytoskeleton and the plasma membrane, which...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cytoskeleton (Hoboken, N.J.) N.J.), 2016-05, Vol.73 (5), p.258-268
Hauptverfasser: Lopez-Ortega, O, Ovalle-Garcia, E, Ortega-Blake, I, Antillon, A, Chavez-Munguia, B, Patino-Lopez, G, Fragoso-Soriano, R, Santos-Argumedo, L
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:B‐lymphocytes are migrating cells that specialize in antigen presentation, antibody secretion, and endocytosis; these processes implicate the modulation of plasma membrane elasticity. Cell stiffness is a force generated by the interaction between the actin‐cytoskeleton and the plasma membrane, which requires the participation of several proteins. These proteins include class I myosins, which are now considered to play a role in controlling membrane–cytoskeleton interactions. In this study, we identified the motor protein Myosin 1g (Myo1g) as a mediator of this phenomenon. The absence of Myo1g decreased the cell stiffness, affecting cell adhesion, cell spreading, phagocytosis, and endocytosis in B‐lymphocytes. The results described here reveal a novel molecular mechanism by which Myo1g mediates and regulates cell stiffness in B‐lymphocytes. © 2016 Wiley Periodicals, Inc.
ISSN:1949-3584
1949-3592
DOI:10.1002/cm.21299