Reliability of immunocytochemistry and fluorescence in situ hybridization on fine-needle aspiration cytology samples of breast cancers: A comparative study

Introduction To characterize breast tumors and metastases, fine‐needle aspiration cytology (FNAB) can be a favorable first choice. However, the diagnostic accuracy of ancillary tests applied to FNAB samples is yet to be validated. Patients and Methods We examined 110 breast cancer patients' pai...

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Veröffentlicht in:	Diagnostic cytopathology 2016-06, Vol.44 (6), p.466-471
Hauptverfasser:	Acs, Balazs, Szekely, Nora, Szasz, Attila Marcell, Lotz, Gabor, Szekely, Tamas, Istok, Roland, Szekely, Eszter, Madaras, Lilla, Kulka, Janina, Jaray, Balazs
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biopsy, Fine-Needle breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology cytology Female fine-needle aspiration biopsy fluorescence in situ hybridization Humans immunocytochemistry Immunohistochemistry In Situ Hybridization, Fluorescence Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Reproducibility of Results Sensitivity and Specificity surgical resection specimen
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Zusammenfassung:	Introduction To characterize breast tumors and metastases, fine‐needle aspiration cytology (FNAB) can be a favorable first choice. However, the diagnostic accuracy of ancillary tests applied to FNAB samples is yet to be validated. Patients and Methods We examined 110 breast cancer patients' paired cytological and surgical resection specimens evaluated between 2005 and 2014. Comparison of ER and Her2 immunocytochemical (ICC) and immunohistochemical (IHC) staining and HER2 fluorescence in situ hybridization (FISH) was performed. Results Significant difference (p
ISSN:	8755-1039 1097-0339
DOI:	10.1002/dc.23463