Tamoxifen citrate induced sperm shape abnormalities in the in vivo mouse

The genotoxic potential of an anticancer drug, tamoxifen citrate, was studied in the in vivo mouse system using the sperm abnormality assay. Sperms of Swiss albino mice were examined after 5 weeks of repeated administration of different doses of the drug for 10 days. The doses used were 0.1, 0.2, 0....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Mutation research 2001-05, Vol.492 (1), p.1-6
Hauptverfasser:	Padmalatha Rai, S, Vijayalaxmi, K.K
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antineoplastic Agents, Hormonal - administration & dosage Antineoplastic Agents, Hormonal - toxicity Biological and medical sciences Body Weight - drug effects Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Male Medical sciences Mice Miscellaneous (drug allergy, mutagens, teratogens...) Mutagenicity Tests Mutagens - administration & dosage Mutagens - toxicity Organ Size - drug effects Pharmacology. Drug treatments Sperm abnormality Sperm Count Spermatozoa - drug effects Spermatozoa - pathology Swiss albino mice Tamoxifen - administration & dosage Tamoxifen - toxicity Tamoxifen citrate Testis - drug effects Testis - pathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The genotoxic potential of an anticancer drug, tamoxifen citrate, was studied in the in vivo mouse system using the sperm abnormality assay. Sperms of Swiss albino mice were examined after 5 weeks of repeated administration of different doses of the drug for 10 days. The doses used were 0.1, 0.2, 0.4 and 0.8 mg/kg b.w. per day. Statistically significant sperm abnormalities revealed the genotoxic potency of this drug.
ISSN:	1383-5718 0027-5107 1879-3592
DOI:	10.1016/S1383-5718(00)00160-1