Waning protection of influenza vaccine against mild laboratory confirmed influenza A(H3N2) and B in Spain, season 2014–15

Waning protection of influenza vaccine against mild laboratory confirmed influenza A(H3N2) and B in Spain, season 2014–15

Highlights • The 2014/15 influenza season in Spain was dominated by drifted A(H3N2) virus. • The influenza vaccine effectiveness was low against influenza A(H3N2) and moderate against B virus. • The influenza vaccine effectiveness decreased in late epidemic stage and with time since vaccination. • T...

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Veröffentlicht in:Vaccine 2016-04, Vol.34 (20), p.2371-2377
Hauptverfasser: Gherasim, Alin, Pozo, Francisco, de Mateo, Salvador, Aspiritxaga Gamarra, Inma, García-Cenoz, Manuel, Vega, Tomas, Martínez, Eva, Giménez, Jaume, Castrillejo, Daniel, Larrauri, Amparo
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Aged
Allergy and Immunology
Antigenic Variation
Case-Control Studies
Child
Child, Preschool
Chronic illnesses
Confidence intervals
Data analysis
Female
Humans
Immune response
Immunization
Infant
Infant, Newborn
Influenza
Influenza A Virus, H3N2 Subtype
Influenza B virus
Influenza vaccine
Influenza Vaccines - therapeutic use
Influenza, Human - prevention & control
Influenza-like illness
Laboratories
Logistic Models
Male
Middle Aged
Observational studies
Seasons
Sentinel Surveillance
Spain - epidemiology
Surveillance
Test negative case–control design
Vaccination - statistics & numerical data
Vaccine effectiveness
Vaccines
Viruses
Waning protection
Young Adult
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Beschreibung
Zusammenfassung:Highlights • The 2014/15 influenza season in Spain was dominated by drifted A(H3N2) virus. • The influenza vaccine effectiveness was low against influenza A(H3N2) and moderate against B virus. • The influenza vaccine effectiveness decreased in late epidemic stage and with time since vaccination. • The decrease of IVE was slower and milder against influenza B than against influenza A(H3N2). • We highlight the importance of the influenza vaccination especially in population risk groups.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2016.03.035