Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease
Highlights • Gastrodin improves learning and memory abilities of Tg2576 mice. • Gastrodin attenuates intracellular oxidative stress in hippocampi of Tg2576 mice. • Gastrodin suppresses BACE1 expression and PKR/eIF2α pathway in hippocampi of Tg2576 mice. • Gastrodin suppresses BACE1 via inhibiting PK...
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| Veröffentlicht in: | Neuroscience 2016-06, Vol.325, p.1-9 |
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| creator | Zhang, J.-S Zhou, S.-F Wang, Q Guo, J.-N Liang, H.-M Deng, J.-B He, W.-Y |
| description | Highlights • Gastrodin improves learning and memory abilities of Tg2576 mice. • Gastrodin attenuates intracellular oxidative stress in hippocampi of Tg2576 mice. • Gastrodin suppresses BACE1 expression and PKR/eIF2α pathway in hippocampi of Tg2576 mice. • Gastrodin suppresses BACE1 via inhibiting PKR/eIF2α in SH-SY5Y cells under oxidative stress. |
| doi_str_mv | 10.1016/j.neuroscience.2016.03.024 |
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Published by Elsevier Ltd. 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Zhou, S.-F ; Wang, Q ; Guo, J.-N ; Liang, H.-M ; Deng, J.-B ; He, W.-Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468t-5af548a6115f11560c29e3b7930e565c567c8cdc4e4121dc84a7ac43873ecca53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Alzheimer Disease - metabolism</topic><topic>Alzheimer’s disease</topic><topic>Amyloid Precursor Protein Secretases - metabolism</topic><topic>Animals</topic><topic>Aspartic Acid Endopeptidases - metabolism</topic><topic>BACE1</topic><topic>Benzyl Alcohols - administration & dosage</topic><topic>Cell Line, Tumor</topic><topic>Disease Models, Animal</topic><topic>eIF-2 Kinase - metabolism</topic><topic>eIF2α</topic><topic>Gastrodia elata</topic><topic>gastrodin</topic><topic>Glucosides - administration & dosage</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Humans</topic><topic>Maze Learning - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Transgenic</topic><topic>Neurology</topic><topic>Oxidative Stress</topic><topic>PKR</topic><topic>Signal Transduction - drug effects</topic><topic>Spatial Memory - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, J.-S</creatorcontrib><creatorcontrib>Zhou, S.-F</creatorcontrib><creatorcontrib>Wang, Q</creatorcontrib><creatorcontrib>Guo, J.-N</creatorcontrib><creatorcontrib>Liang, H.-M</creatorcontrib><creatorcontrib>Deng, J.-B</creatorcontrib><creatorcontrib>He, W.-Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, J.-S</au><au>Zhou, S.-F</au><au>Wang, Q</au><au>Guo, J.-N</au><au>Liang, H.-M</au><au>Deng, J.-B</au><au>He, W.-Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease</atitle><jtitle>Neuroscience</jtitle><addtitle>Neuroscience</addtitle><date>2016-06-14</date><risdate>2016</risdate><volume>325</volume><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>0306-4522</issn><eissn>1873-7544</eissn><abstract>Highlights • Gastrodin improves learning and memory abilities of Tg2576 mice. • Gastrodin attenuates intracellular oxidative stress in hippocampi of Tg2576 mice. • Gastrodin suppresses BACE1 expression and PKR/eIF2α pathway in hippocampi of Tg2576 mice. • Gastrodin suppresses BACE1 via inhibiting PKR/eIF2α in SH-SY5Y cells under oxidative stress.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>26987953</pmid><doi>10.1016/j.neuroscience.2016.03.024</doi><tpages>9</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Alzheimer Disease - metabolism Alzheimer’s disease Amyloid Precursor Protein Secretases - metabolism Animals Aspartic Acid Endopeptidases - metabolism BACE1 Benzyl Alcohols - administration & dosage Cell Line, Tumor Disease Models, Animal eIF-2 Kinase - metabolism eIF2α Gastrodia elata gastrodin Glucosides - administration & dosage Hippocampus - drug effects Hippocampus - metabolism Humans Maze Learning - drug effects Mice Mice, Inbred C57BL Mice, Transgenic Neurology Oxidative Stress PKR Signal Transduction - drug effects Spatial Memory - drug effects |
| title | Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease |
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