Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease

Highlights • Gastrodin improves learning and memory abilities of Tg2576 mice. • Gastrodin attenuates intracellular oxidative stress in hippocampi of Tg2576 mice. • Gastrodin suppresses BACE1 expression and PKR/eIF2α pathway in hippocampi of Tg2576 mice. • Gastrodin suppresses BACE1 via inhibiting PK...

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Veröffentlicht in:	Neuroscience 2016-06, Vol.325, p.1-9
Hauptverfasser:	Zhang, J.-S, Zhou, S.-F, Wang, Q, Guo, J.-N, Liang, H.-M, Deng, J.-B, He, W.-Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer’s disease Amyloid Precursor Protein Secretases - metabolism Animals Aspartic Acid Endopeptidases - metabolism BACE1 Benzyl Alcohols - administration & dosage Cell Line, Tumor Disease Models, Animal eIF-2 Kinase - metabolism eIF2α Gastrodia elata gastrodin Glucosides - administration & dosage Hippocampus - drug effects Hippocampus - metabolism Humans Maze Learning - drug effects Mice Mice, Inbred C57BL Mice, Transgenic Neurology Oxidative Stress PKR Signal Transduction - drug effects Spatial Memory - drug effects
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Zusammenfassung:	Highlights • Gastrodin improves learning and memory abilities of Tg2576 mice. • Gastrodin attenuates intracellular oxidative stress in hippocampi of Tg2576 mice. • Gastrodin suppresses BACE1 expression and PKR/eIF2α pathway in hippocampi of Tg2576 mice. • Gastrodin suppresses BACE1 via inhibiting PKR/eIF2α in SH-SY5Y cells under oxidative stress.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.03.024