Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice
Highlights • Hippocampal LTP is impaired in adult, but not adolescent, DAKO mice. • Impaired LTP is associated with spine elongation in adult DAKO mice. • Hippocampal learning is compromised in adult but not adolescent DAKO mice. • Drebrin A critically supports hippocampal functions in adult mice....
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| Veröffentlicht in: | Neuroscience 2016-06, Vol.324, p.218-226 |
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| creator | Kojima, N Yasuda, H Hanamura, K Ishizuka, Y Sekino, Y Shirao, T |
| description | Highlights • Hippocampal LTP is impaired in adult, but not adolescent, DAKO mice. • Impaired LTP is associated with spine elongation in adult DAKO mice. • Hippocampal learning is compromised in adult but not adolescent DAKO mice. • Drebrin A critically supports hippocampal functions in adult mice. |
| doi_str_mv | 10.1016/j.neuroscience.2016.03.015 |
| format | Article |
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| subjects | Aging - drug effects Aging - pathology Aging - physiology Aging - psychology Animals Conditioning (Psychology) - physiology Dendrites - drug effects Dendrites - pathology Dendrites - physiology drebrin A drebrin E Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fear - physiology fear learning hippocampus Hippocampus - drug effects Hippocampus - growth & development Hippocampus - pathology Hippocampus - physiology isoform conversion Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Mice, Inbred C57BL Mice, Knockout Neurology Neuropeptides - genetics Neuropeptides - metabolism Protein Isoforms synaptic plasticity Tissue Culture Techniques |
| title | Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice |
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