Drebrin A regulates hippocampal LTP and hippocampus-dependent fear learning in adult mice

Highlights • Hippocampal LTP is impaired in adult, but not adolescent, DAKO mice. • Impaired LTP is associated with spine elongation in adult DAKO mice. • Hippocampal learning is compromised in adult but not adolescent DAKO mice. • Drebrin A critically supports hippocampal functions in adult mice....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2016-06, Vol.324, p.218-226
Hauptverfasser:	Kojima, N, Yasuda, H, Hanamura, K, Ishizuka, Y, Sekino, Y, Shirao, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - drug effects Aging - pathology Aging - physiology Aging - psychology Animals Conditioning (Psychology) - physiology Dendrites - drug effects Dendrites - pathology Dendrites - physiology drebrin A drebrin E Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology Fear - physiology fear learning hippocampus Hippocampus - drug effects Hippocampus - growth & development Hippocampus - pathology Hippocampus - physiology isoform conversion Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Mice, Inbred C57BL Mice, Knockout Neurology Neuropeptides - genetics Neuropeptides - metabolism Protein Isoforms synaptic plasticity Tissue Culture Techniques
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Hippocampal LTP is impaired in adult, but not adolescent, DAKO mice. • Impaired LTP is associated with spine elongation in adult DAKO mice. • Hippocampal learning is compromised in adult but not adolescent DAKO mice. • Drebrin A critically supports hippocampal functions in adult mice.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.03.015