Calbindin-D-28K like immunoreactivity in superficial dorsal horn neurons and effects of sciatic chronic constriction injury

Highlights • Calbindin D-28K is found in 30% of neurons in spinal dorsal laminae I and II. • Calbindin does not associate with specific electrophysiological phenotype. • Calbindin may associate with putative excitatory neurons and is found in some radial, vertical and central neurons. • Calbindin co...

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Veröffentlicht in:	Neuroscience 2016-06, Vol.324, p.330-343
Hauptverfasser:	Stebbing, M.J, Balasubramanyan, S, Smith, P.A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Nuclear - metabolism Calbindin 1 - metabolism calcium-binding protein Cell Count Chronic Disease Disease Models, Animal electrophysiology Excitatory Postsynaptic Potentials - physiology Female Immunohistochemistry Male Microscopy, Fluorescence Nerve Compression Syndromes - metabolism Nerve Compression Syndromes - pathology nerve injury Nerve Tissue Proteins - metabolism Neurology neuronal morphology neuropathic pain Patch-Clamp Techniques Posterior Horn Cells - metabolism Posterior Horn Cells - pathology Rats, Sprague-Dawley Sciatic Nerve - injuries Sciatic Nerve - metabolism Sciatic Nerve - pathology substantia gelatinosa Tissue Culture Techniques
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Zusammenfassung:	Highlights • Calbindin D-28K is found in 30% of neurons in spinal dorsal laminae I and II. • Calbindin does not associate with specific electrophysiological phenotype. • Calbindin may associate with putative excitatory neurons and is found in some radial, vertical and central neurons. • Calbindin containing neurons receive relatively weak excitatory synaptic drive. • Altered synaptic drive to calbindin neurons does not contribute to central sensitization in neuropathic pain.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.03.016