Synaptic abnormalities of mice lacking toll-like receptor (TLR)-9

Highlights • A novel role of toll-like receptor (TLR) 9 in synaptic plasticity and efficacy is proposed. • Nerve stimulation of TLR9 KO muscles produced weaker force compared to wild type. • NMJs, studied as a model synapse, showed pre-synaptic and post-synaptic defects in TLR9 KO mice. • Presynapti...

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Veröffentlicht in:	Neuroscience 2016-06, Vol.324, p.1-10
Hauptverfasser:	Patel, V, Patel, A.M, McArdle, J.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - metabolism Animals Electric Stimulation Female Male Mice, Knockout Microscopy, Confocal Miniature Postsynaptic Potentials - physiology Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Neurology neuromuscular junction Neuromuscular Junction - pathology Neuromuscular Junction - physiology Neuronal Plasticity - physiology Patch-Clamp Techniques Presynaptic Terminals - pathology Presynaptic Terminals - physiology synapse synaptic abnormality Synaptic Vesicles - pathology Synaptic Vesicles - physiology Tissue Culture Techniques TLR9 Toll-Like Receptor 9 - deficiency Toll-Like Receptor 9 - genetics toll-like receptors vesicle dynamics
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Zusammenfassung:	Highlights • A novel role of toll-like receptor (TLR) 9 in synaptic plasticity and efficacy is proposed. • Nerve stimulation of TLR9 KO muscles produced weaker force compared to wild type. • NMJs, studied as a model synapse, showed pre-synaptic and post-synaptic defects in TLR9 KO mice. • Presynaptic defects included abnormal spontaneous and evoked vesicle release. • Endplate volume, as measured by α-bungarotoxin staining, declined.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.03.001