Altered expression of miR-125a-5p in thymoma-associated myasthenia gravis and its down-regulation of foxp3 expression in Jurkat cells
Highlights • We identified 137 miRNAs differentially expressed in thymoma of TAMG patients. • MiR-125a-5 was one of upregulated miRNAs in 137 dysregulated miRNAs. • MiR-125a-5p can target foxp3 3′UTR. • MiR-125a-5p may be involved in the thymic pathogenesis of TAMG by targeting foxp3.
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| Veröffentlicht in: | Immunology letters 2016-04, Vol.172, p.47-55 |
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| container_title | Immunology letters |
| container_volume | 172 |
| creator | Li, Jinpin Qiu, Di Chen, Zezhi Du, Weiwei Liu, Jingli Mo, Xuean |
| description | Highlights • We identified 137 miRNAs differentially expressed in thymoma of TAMG patients. • MiR-125a-5 was one of upregulated miRNAs in 137 dysregulated miRNAs. • MiR-125a-5p can target foxp3 3′UTR. • MiR-125a-5p may be involved in the thymic pathogenesis of TAMG by targeting foxp3. |
| doi_str_mv | 10.1016/j.imlet.2016.02.005 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Immunology letters, 2016-04, Vol.172, p.47-55 |
| issn | 0165-2478 1879-0542 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | 3' Untranslated Regions - genetics Allergy and Immunology Cell Movement Cell Proliferation Computational Biology Down-Regulation Female Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Foxp3 Humans Jurkat Cells Male Microarray Analysis MicroRNAs - genetics MiR-125a-5p Myasthenia gravis (MG) Myasthenia Gravis - genetics Thymoma Thymoma - genetics |
| title | Altered expression of miR-125a-5p in thymoma-associated myasthenia gravis and its down-regulation of foxp3 expression in Jurkat cells |
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