Altered expression of miR-125a-5p in thymoma-associated myasthenia gravis and its down-regulation of foxp3 expression in Jurkat cells

Highlights • We identified 137 miRNAs differentially expressed in thymoma of TAMG patients. • MiR-125a-5 was one of upregulated miRNAs in 137 dysregulated miRNAs. • MiR-125a-5p can target foxp3 3′UTR. • MiR-125a-5p may be involved in the thymic pathogenesis of TAMG by targeting foxp3.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2016-04, Vol.172, p.47-55
Hauptverfasser:	Li, Jinpin, Qiu, Di, Chen, Zezhi, Du, Weiwei, Liu, Jingli, Mo, Xuean
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Allergy and Immunology Cell Movement Cell Proliferation Computational Biology Down-Regulation Female Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Foxp3 Humans Jurkat Cells Male Microarray Analysis MicroRNAs - genetics MiR-125a-5p Myasthenia gravis (MG) Myasthenia Gravis - genetics Thymoma Thymoma - genetics
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Beschreibung
Zusammenfassung:	Highlights • We identified 137 miRNAs differentially expressed in thymoma of TAMG patients. • MiR-125a-5 was one of upregulated miRNAs in 137 dysregulated miRNAs. • MiR-125a-5p can target foxp3 3′UTR. • MiR-125a-5p may be involved in the thymic pathogenesis of TAMG by targeting foxp3.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2016.02.005