A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells

Highlights • We generated mice with PKK knockout in B cells. • PKK deficiency results in reduction of recirculating mature B cells. • PKK deficiency also leads to a decrease in peritoneal B1 cells. • PKK plays a critical role in BCR-mediated proliferation and survival of B cells.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2016-04, Vol.172, p.67-78
Hauptverfasser:	Chen, Luojing, Oleksyn, David, Pulvino, Mary, Sanz, Ignacio, Ryan, Daniel, Ryan, Charlotte, Lin, Chyuan-sheng, Poligone, Brian, Pentland, Alice P, Ritchlin, Christopher, Zhao, Jiyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Antigens, CD19 - genetics B cells B-Lymphocytes - physiology B1 cells Cell Differentiation Cell Proliferation - genetics Cells, Cultured Germinal Center - immunology Immunologic Memory Lymphocyte Activation Mice Mice, Inbred C57BL Mice, Knockout NF-kappa B - metabolism PKK Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Receptors, Antigen, B-Cell - metabolism Recirculating mature B cells
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Beschreibung
Zusammenfassung:	Highlights • We generated mice with PKK knockout in B cells. • PKK deficiency results in reduction of recirculating mature B cells. • PKK deficiency also leads to a decrease in peritoneal B1 cells. • PKK plays a critical role in BCR-mediated proliferation and survival of B cells.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2016.02.015