Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4‑b]quinoline Hybrid Heterocycles

Multicomponent Dipolar Cycloaddition Strategy: Combinatorial Synthesis of Novel Spiro-Tethered Pyrazolo[3,4‑b]quinoline Hybrid Heterocycles

The stereoselective syntheses of a library of novel spiro-tethered pyrazolo­[3,4-b]­quinoline–pyrrolidine/pyrrolothiazole/indolizine–oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from α-amino acids and 1,2-di...

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Veröffentlicht in:ACS combinatorial science 2016-05, Vol.18 (5), p.262-270
Hauptverfasser: Sumesh, Remani Vasudevan, Muthu, Muthumani, Almansour, Abdulrahman I, Suresh Kumar, Raju, Arumugam, Natarajan, Athimoolam, S, Jeya Yasmi Prabha, E. Arockia, Kumar, Raju Ranjith
Format: Artikel
Sprache:eng
Schlagworte:
Azo Compounds
Combinatorial Chemistry Techniques - methods
Cycloaddition Reaction - methods
Heterocyclic Compounds - chemical synthesis
Quinolines - chemical synthesis
Small Molecule Libraries - chemical synthesis
Spiro Compounds
Stereoisomerism
Thiosemicarbazones
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Zusammenfassung:The stereoselective syntheses of a library of novel spiro-tethered pyrazolo­[3,4-b]­quinoline–pyrrolidine/pyrrolothiazole/indolizine–oxindole/acenaphthene hybrid heterocycles have been achieved through the 1,3-dipolar cycloaddition of azomethine ylides generated in situ from α-amino acids and 1,2-diketones to dipolarophiles derived from pyrazolo­[3,4-b]­quinoline derivatives.
ISSN:2156-8952
2156-8944
DOI:10.1021/acscombsci.6b00003