Effect of the carbon sources on the growth kinetics of Cephalosporium acremonium in the cephalosporin C production process

The growth phase of Cephalosporium acremonium ATCC 48272 was analyzed in the batch production process of cephalosporin C. Two media were used: one containing glucose and sucrose as main sources of carbon and energy, and the other containing only glucose. The consumption rate of glucose to form biomass was much higher in medium containing only glucose. The behavior in both media could be satisfactorily explained through simulation of a model which included inhibition of glucose consumption by sucrose in the classical Contois kinetics.