Clinical and pathological significance of N-Myc downstream-regulated gene 2 (NDRG2) in diverse human cancers

Clinical and pathological significance of N-Myc downstream-regulated gene 2 (NDRG2) in diverse human cancers

Human N - Myc downstream - regulated gene 2 ( NDRG2 ), located at chromosome 14q11.2, has been reported to be down-regulated and associated with the progression and prognosis of diverse cancers. Collectively, previous studies suggest that NDRG2 functions as a candidate tumor-suppressor gene; thus, u...

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Veröffentlicht in:Apoptosis (London) 2016-06, Vol.21 (6), p.675-682
Hauptverfasser: Hu, Wei, Yang, Yang, Fan, Chongxi, Ma, Zhiqiang, Deng, Chao, Li, Tian, Lv, Jianjun, Yao, Weiwei, Gao, Jianyuan
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Biomedical and Life Sciences
Biomedical engineering
Biomedicine
Cancer
Cancer Research
Cell Biology
Development and progression
Gene Expression Regulation, Neoplastic
Genes
Genetic aspects
Genetic research
Health aspects
Humans
Medical colleges
Neoplasms - classification
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Oncology
Oncology, Experimental
Prognosis
Review
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
Virology
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Zusammenfassung:Human N - Myc downstream - regulated gene 2 ( NDRG2 ), located at chromosome 14q11.2, has been reported to be down-regulated and associated with the progression and prognosis of diverse cancers. Collectively, previous studies suggest that NDRG2 functions as a candidate tumor-suppressor gene; thus, up-regulation of NDRG2 protein might act as a promising therapeutic strategy for malignant tumors. The aim of this review was to comprehensively present the clinical and pathological significance of NDRG2 in human cancers.
ISSN:1360-8185
1573-675X
DOI:10.1007/s10495-016-1244-3