Non-Hodgkin lymphoma and benzene exposure: A systematic literature review

Epidemiological papers that address an association between benzene exposure and non-Hodgkin lymphoma (NHL) were identified and separated by study design. Eighteen studies contained 21 study groups—11 population-based case–control study groups, 3 nested occupation-based case–control study groups and 7 occupational benzene cohort study groups. Petroleum industry studies were not included. Only two of these 21 study groups showed statistically significant associations. However, these were among workers with multiple exposures across industries. Eleven of the 21 study groups presented ratios less than one, two equaled one, and eight were greater than one. Over all, about as many cases were observed (404) as expected (390.0) for an observed to expected ratio of 1.04 (0.94–1.14). After removal of the studies with multiple chemical exposures problems, the observed was 359 cases with 373.2 cases expected, yielding an odds ratio of 0.96 (0.86–1.06). Further assessment of an association with NHL should document the benzene exposure and separate out the contribution of non-benzene exposures.