The effect of retinol on hepatic and renal drug-metabolising enzymes

The effect of retinol on hepatic and renal drug-metabolising enzymes

Retinol pretreatment (75 mg/kg/day, 4 days) potentiated paracetamol-induced hepatotoxicity in BALB/c mice (alanine aminotransferase (ALT) activity; 2510 ± 602 vs 1155 ± 282 IU/l; retinol+paracetamol vs corn oil+paracetamol, respectively, P

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Bibliographische Detailangaben
Veröffentlicht in:Food and chemical toxicology 2001, Vol.39 (1), p.1-9
Hauptverfasser: Bray, B.J, Goodin, M.G, Inder, R.E, Rosengren, R.J
Format: Artikel
Sprache:eng
Schlagworte:
Acetaminophen - metabolism
Acetaminophen - toxicity
Alanine Transaminase - metabolism
Analgesics, Non-Narcotic - toxicity
Animals
Biological and medical sciences
Blood Urea Nitrogen
Creatinine - blood
Cytochrome P-450 CYP1A2 - metabolism
Cytochrome P-450 CYP2E1 - metabolism
Cytochrome P-450 Enzyme System - metabolism
Cytochrome P450
Drug Synergism
Food toxicology
Glutathione - metabolism
Hepatotoxicity
Kidney - drug effects
Kidney - enzymology
Liver - drug effects
Liver - enzymology
Male
Medical sciences
Mice
Mice, Inbred BALB C
Organ Specificity - drug effects
Paracetamol
Protein Isoforms
Retinol
Toxicology
Vitamin A - therapeutic use
Vitamin A - toxicity
Zea mays
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Zusammenfassung:Retinol pretreatment (75 mg/kg/day, 4 days) potentiated paracetamol-induced hepatotoxicity in BALB/c mice (alanine aminotransferase (ALT) activity; 2510 ± 602 vs 1155 ± 282 IU/l; retinol+paracetamol vs corn oil+paracetamol, respectively, P
ISSN:0278-6915
1873-6351
DOI:10.1016/S0278-6915(00)00110-1