A novel solvent-dependently bifunctional NIR absorptive and fluorescent ratiometric probe for detecting Fe3+/Cu2+ and its application in bioimaging

A novel solvent-dependently bifunctional NIR absorptive and fluorescent ratiometric probe for detecting Fe3+/Cu2+ and its application in bioimaging

A novel rhodamine-cyanine based probe LS1 was designed and synthesized, which can act as a bifunctional NIR ratiometric colorimetric and fluorescent probe for detecting Fe3+ and Cu2+ in solvent of MeOH/H2O and MeCN/H2O respectively. As expected, it exhibited high selectivity and sensitivity for dete...

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Veröffentlicht in:Sensors and actuators. B, Chemical Chemical, 2016-03, Vol.224, p.661-667
Hauptverfasser: Li, Shao, Zhang, Di, Xie, Xinyu, Ma, Saige, Liu, Yao, Xu, Zhanhui, Gao, Yanfeng, Ye, Yong
Format: Artikel
Sprache:eng
Schlagworte:
Absorptivity
Actuators
Colorimetry
Cu2
Cyanine
Fe3
Fluorescence
Fluorescent probe
Imaging
Medical imaging
NIR
Rhodamine
Sensors
Solvents
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Zusammenfassung:A novel rhodamine-cyanine based probe LS1 was designed and synthesized, which can act as a bifunctional NIR ratiometric colorimetric and fluorescent probe for detecting Fe3+ and Cu2+ in solvent of MeOH/H2O and MeCN/H2O respectively. As expected, it exhibited high selectivity and sensitivity for detecting Fe3+ and Cu2+ over other commonly coexistent metal ions in their respective systems with a broad pH span. The detection limit was measured to be 0.737μM for Fe3+ and 1.019μM for Cu2+. Furthermore, fluorescence imaging experiments of Cu2+ ions in living SH-SY5Y109 cells demonstrated its value of practical application in biological systems.
ISSN:0925-4005
1873-3077
DOI:10.1016/j.snb.2015.10.086