Fluorophore-photochrome co-embedded polymer nanoparticles for photoswitchable fluorescence bioimaging
Photoswitchable polymer nanoparticles (ps-PNPs) have been constructed by emulsion polymerization through embedding an iridium(III) complex, [Ir(bt) 2 (pic)](bt = phenylbenzothiazole, pic = picolinate), as a fluorophore and a diarylethene derivative (DTE) as a photochrome. The ps-PNPs show reversible...
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Veröffentlicht in: | Nano research 2012-07, Vol.5 (7), p.494-503 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Photoswitchable polymer nanoparticles (ps-PNPs) have been constructed by emulsion polymerization through embedding an iridium(III) complex, [Ir(bt)
2
(pic)](bt = phenylbenzothiazole, pic = picolinate), as a fluorophore and a diarylethene derivative (DTE) as a photochrome. The ps-PNPs show reversible luminescence modulation with DTE switching using UV light in aqueous solution and even in living cells. Such luminescent modulation only occurred in polymer nanoparticles and not in a simple mixed solution with low concentrations of [Ir(bt)
2
(pic)] and DTE. The ps-PNPs displayed good cellular uptake and fast intracellular luminescence modulation by photoswitching, indicating the nanoparticles could be developed as photoswitchable luminescent probes for a diversity of bioimaging applications. |
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ISSN: | 1998-0124 1998-0000 |
DOI: | 10.1007/s12274-012-0235-0 |