Mannose Receptor Mediates the Cellular Immune Response in Human Coccidioidomycosis

Mannose is the predominant monosaccharide in the coccidioidal antigen preparation T27K. Mannan and anti-CD206 antibody significantly decreased the surface expression of mannose receptor (MR) on adherent peripheral blood mononuclear cells and reduced the interleukin-2 (IL-2) release induced by T27K....

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Veröffentlicht in:	Infection and Immunity 2005-04, Vol.73 (4), p.2554-2555
Hauptverfasser:	Ampel, Neil M, Nelson, Daniel K, Li, Lijin, Dionne, Sara O, Lake, Douglas F, Simmons, Keira A, Pappagianis, Demosthenes
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, Fungal - immunology Coccidioides Coccidioidomycosis - immunology Fungal and Parasitic Infections Humans Interleukin-2 - biosynthesis Lectins, C-Type - physiology Mannose Receptor Mannose-Binding Lectins - physiology Receptors, Cell Surface - physiology
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Beschreibung
Zusammenfassung:	Mannose is the predominant monosaccharide in the coccidioidal antigen preparation T27K. Mannan and anti-CD206 antibody significantly decreased the surface expression of mannose receptor (MR) on adherent peripheral blood mononuclear cells and reduced the interleukin-2 (IL-2) release induced by T27K. These data suggest that MR mediates IL-2 release by T27K.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.73.4.2554-2555.2005