Methyl Substitution Regulates the Enantioselectivity of Supramolecular Complex Binding to Human Telomeric G-Quadruplex DNA

Chiral supramolecular compounds with substituents at different positions show different binding properties with human telomeric G‐quadruplex DNA. These different positions of methyl substitution in chiral supramolecular compounds can modulate their enantioselectivity and structural preference when binding with human telomeric G‐quadruplex DNA. Get selective! Chiral supramolecular compounds with substituents at different positions show distinct binding properties. The substitution of a methyl group at different positions on chiral supramolecular compounds can modulate their enantioselectivity and structural preference when binding with human telomeric G‐quadruplex DNA (see scheme).