Antitumor characterization of various fractions of Launaea procumbens

Antitumor characterization of various fractions of Launaea procumbens

The antitumor activity of various six fractions of Launaea procumbens were studied using the potato disk bioassay technique. Three concentrations (10, 100, and 1000 ppm) of all these six fractions were used for characterization of antitumor activity. Among these fractions, methanolic fraction exhibi...

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Veröffentlicht in:Toxicology and industrial health 2016-01, Vol.32 (1), p.188-191
Hauptverfasser: Khan, Rahmat Ali, Khan, Muhammad Rashid, Shah, Naseer Ali, Sahreen, Sumaira, Elahi, Sadaf Noor
Format: Artikel
Sprache:eng
Schlagworte:
Agrobacterium tumefaciens
Agrobacterium tumefaciens - drug effects
Anticancer properties
Asteraceae - chemistry
Biocompatibility
Biological Assay
Butanes - chemistry
Disks
Dose-Response Relationship, Drug
Gall
Inhibition
Inhibitory Concentration 50
Launaea
Methane - chemistry
Plant Extracts - pharmacology
Plant Tumors
Purification
Solanum tuberosum
Solanum tuberosum - drug effects
Tumors
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Zusammenfassung:The antitumor activity of various six fractions of Launaea procumbens were studied using the potato disk bioassay technique. Three concentrations (10, 100, and 1000 ppm) of all these six fractions were used for characterization of antitumor activity. Among these fractions, methanolic fraction exhibited significant inhibition of crown gall tumors caused by Agrobacterium tumefaciens followed by butanolic fraction. These results revealed that methanolic and butanolic fractions contain bioactive constituents responsible for inhibition of tumor. Further purification and characterization are in progress in our laboratory.
ISSN:0748-2337
1477-0393
DOI:10.1177/0748233713500823