Catalytic Kinetic Resolution of Biaryl Compounds

Biaryl compounds with axial chirality are very common in synthetic chemistry, especially in catalysis. Axially chiral biaryls are important due to their biological activities and extensive applications in asymmetric catalysis. Thus the development of efficient enantioselective methods for their synthesis has attracted considerable attention. This Minireview discusses the progress made in catalytic kinetic resolution of biaryl compounds and chronicles significant advances made recently in catalytic kinetic resolution of biaryl scaffolds. Roll out the biaryls: Axially chiral biaryls are very attractive due to their wide applications in asymmetric catalysis. The development of efficient enantioselective syntheses of chiral biaryls has attracted considerable attention. This Minireview highlights recent progress achieved in the field of catalytic kinetic resolution of biaryl compounds.