Ring-opening Fluorination of Cyclobutanols and Cyclopropanols Catalyzed by Silver

Cyclobutanols and cyclopropanols underwent ring-opening fluorination upon treatment with Selectfluor in the presence of a substoichiometric amount of a silver salt. The reaction provides an efficient method to synthesize γ- and β-fluoroalkyl ketones.

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Veröffentlicht in:Chemistry letters 2015-06, Vol.44 (6), p.821-823
Hauptverfasser: Ishida, Naoki, Okumura, Shintaro, Nakanishi, Yuuta, Murakami, Masahiro
Format: Artikel
Sprache:eng
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Zusammenfassung:Cyclobutanols and cyclopropanols underwent ring-opening fluorination upon treatment with Selectfluor in the presence of a substoichiometric amount of a silver salt. The reaction provides an efficient method to synthesize γ- and β-fluoroalkyl ketones.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.150138