Sensing Protein Surfaces with Targeted Fluorescent Receptors

Invited for the cover of this issue is the group of David Margulies at the Weizmann Institute of Science (Israel). The image highlights the analogy between fluorescent molecular sensors and a miniaturized camera that can capture changes that occur at the nanoscale and shed light on the structural state of proteins. Read the full text of the article at 10.1002/chem.201502069. “We believe that the concept of combining a highly specific and a non‐specific protein binder on a single molecular platform could open up new possibilities for detecting proteins and/or regulating their functions.” Read more about the story behind the cover in the Cover Profile and about the research itself on page 15981 ff. (DOI: 10.1002/chem.201502069).