Enantio- and Diastereoselective Formal Hetero-Diels-Alder Reactions of Trifluoromethylated Enones Catalyzed by Chiral Primary Amines

Enantioselective formal hetero‐Diels‐Alder reactions of trifluoromethylated enones and 2‐amino‐1,3‐butadienes generated in situ from aliphatic acyclic enones and chiral primary amines are reported. The corresponding tetrahydropyran‐4‐ones are formed in up to 94 % yield and with up to 94 % ee. The re...

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Veröffentlicht in:	Chemistry : a European journal 2015-08, Vol.21 (33), p.11773-11778
Hauptverfasser:	Lin, Yong-Jun, Du, Li-Na, Kang, Tai-Ran, Liu, Quan-Zhong, Chen, Ze-Qin, He, Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Activated Aliphatic compounds Amines Carbonyl groups Chemical reactions Chemistry Chromatography Condensing enantioselectivity enones hydrogen bonds Ketones Mathematical analysis organocatalysis oxygen heterocycles
Online-Zugang:	Volltext
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