The Role of Endometrial Biopsy in the Preoperative Detection of Uterine Leiomyosarcoma

Abstract Study Objective To assess the sensitivity of preoperative endometrial biopsy in detection of uterine leiomyosarcoma (ULMS). Study Design Retrospective analysis of a prospectively collected database (Canadian Task Force III). Setting Two academic tertiary referral centers. Patients All cases of ULMS treated at participating institutions between January 2005 and August 2012 were identified following IRB approval. Interventions Abstracted data included demographics, preoperative evaluation, presenting symptom, surgical management, pathology and clinical outcomes. Chi-square tests were used for statistical analysis. Measurements and Main Results 329 cases were identified, of which 152 cases had complete pathologic data available for review. Sixty-eight (45%) of 152 patients had endometrial sampling prior to surgery. Patients with postmenopausal bleeding were significantly more likely to be biopsied preoperatively (51.6% vs 9.5%, p =