The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters
Highlights • Genistein induces ABCC1 and ABCG2 protein expression in breast cancer cell lines. • ABCG2 induction leads to enhanced chemoresistance to doxorubicin and mitoxantrone. • Transporter induction takes places at the translational level and is miRNA-mediated • The effect is independent of cla...
Gespeichert in:
| Veröffentlicht in: | Cancer letters 2016-06, Vol.376 (1), p.165-172 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 172 |
|---|---|
| container_issue | 1 |
| container_start_page | 165 |
| container_title | Cancer letters |
| container_volume | 376 |
| creator | Rigalli, Juan Pablo Tocchetti, Guillermo Nicolás Arana, Maite Rocío Villanueva, Silvina Stella Maris Catania, Viviana Alicia Theile, Dirk Ruiz, María Laura Weiss, Johanna |
| description | Highlights • Genistein induces ABCC1 and ABCG2 protein expression in breast cancer cell lines. • ABCG2 induction leads to enhanced chemoresistance to doxorubicin and mitoxantrone. • Transporter induction takes places at the translational level and is miRNA-mediated • The effect is independent of classical estrogen receptors. |
| doi_str_mv | 10.1016/j.canlet.2016.03.040 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1785746135</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0304383516302002</els_id><sourcerecordid>4043852541</sourcerecordid><originalsourceid>FETCH-LOGICAL-c445t-785c32b967dbff0c11247d8c6ec07ab13c8a66b550aabfa584eaf207a408672e3</originalsourceid><addsrcrecordid>eNqFks2O1DAMxyMEYoeFN0AoEhcuLc5394K0jPiSVuLAco7S1J3J0GmHJEWaB-C9SekC0l44RJHjn-3YfxPynEHNgOnXh9q7ccBc82LVIGqQ8IBsWGN4Za4aeEg2IEBWohHqgjxJ6QAAShr1mFxwA0JIpTfk5-0e6Wl_zhOmHKcdjrSckDKGkeK4d6PHRI_zkEMX5x2NmIpzeaUFaCO6lKlf7Eg9DgMdwlgC2jPN0Y1pcDlMoxtK3G5eDTr19PrtdvWfppgxpqfkUe-GhM_u7kvy9f272-3H6ubzh0_b65vKS6lyZRrlBW-vtOnavgfPGJema7xGD8a1TPjGad0qBc61vVONRNfz4pLQaMNRXJJXa95TnL7PpWN7DGn5thtxmpNlpYKRmglV0Jf30MM0x9LKb0orqTVjhZIr5eOUUsTenmI4uni2DOwikz3YVSa7yGRB2CJTCXtxl3xuj9j9DfqjSwHerACWafwIGG3yAcuUuxDRZ9tN4X8V7ifwRZng3fANz5j-9WITt2C_LKuybArTAjgAF78Aa728qw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1786546611</pqid></control><display><type>article</type><title>The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Rigalli, Juan Pablo ; Tocchetti, Guillermo Nicolás ; Arana, Maite Rocío ; Villanueva, Silvina Stella Maris ; Catania, Viviana Alicia ; Theile, Dirk ; Ruiz, María Laura ; Weiss, Johanna</creator><creatorcontrib>Rigalli, Juan Pablo ; Tocchetti, Guillermo Nicolás ; Arana, Maite Rocío ; Villanueva, Silvina Stella Maris ; Catania, Viviana Alicia ; Theile, Dirk ; Ruiz, María Laura ; Weiss, Johanna</creatorcontrib><description>Highlights • Genistein induces ABCC1 and ABCG2 protein expression in breast cancer cell lines. • ABCG2 induction leads to enhanced chemoresistance to doxorubicin and mitoxantrone. • Transporter induction takes places at the translational level and is miRNA-mediated • The effect is independent of classical estrogen receptors.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/j.canlet.2016.03.040</identifier><identifier>PMID: 27033456</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Antineoplastic Agents - pharmacology ; ATP Binding Cassette Transporter, Sub-Family G, Member 2 - biosynthesis ; ATP Binding Cassette Transporter, Sub-Family G, Member 2 - drug effects ; ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics ; Breast cancer ; Breast Neoplasms - drug therapy ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cancer therapies ; Chemoresistance ; Chemotherapy ; Cytotoxicity ; Disease ; Dose-Response Relationship, Drug ; Doxorubicin - pharmacology ; Drug Resistance, Multiple - drug effects ; Drug Resistance, Neoplasm - drug effects ; Drugs ; Estrogens ; Female ; Food-Drug Interactions ; Gene Expression Regulation, Neoplastic ; Genistein ; Genistein - toxicity ; Hematology, Oncology and Palliative Medicine ; Humans ; Life sciences ; MCF-7 Cells ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Mitoxantrone - pharmacology ; Multidrug resistance ; Multidrug Resistance-Associated Proteins - biosynthesis ; Multidrug Resistance-Associated Proteins - drug effects ; Multidrug Resistance-Associated Proteins - genetics ; Neoplasm Proteins - biosynthesis ; Neoplasm Proteins - drug effects ; Neoplasm Proteins - genetics ; Phytoestrogens - toxicity ; Protein Biosynthesis ; Protein Synthesis Inhibitors - pharmacology ; Risk Assessment ; Translational regulation ; Tumors ; Up-Regulation ; Womens health</subject><ispartof>Cancer letters, 2016-06, Vol.376 (1), p.165-172</ispartof><rights>2016 Elsevier Ireland Ltd</rights><rights>Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Jun 28, 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-785c32b967dbff0c11247d8c6ec07ab13c8a66b550aabfa584eaf207a408672e3</citedby><cites>FETCH-LOGICAL-c445t-785c32b967dbff0c11247d8c6ec07ab13c8a66b550aabfa584eaf207a408672e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.canlet.2016.03.040$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27033456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rigalli, Juan Pablo</creatorcontrib><creatorcontrib>Tocchetti, Guillermo Nicolás</creatorcontrib><creatorcontrib>Arana, Maite Rocío</creatorcontrib><creatorcontrib>Villanueva, Silvina Stella Maris</creatorcontrib><creatorcontrib>Catania, Viviana Alicia</creatorcontrib><creatorcontrib>Theile, Dirk</creatorcontrib><creatorcontrib>Ruiz, María Laura</creatorcontrib><creatorcontrib>Weiss, Johanna</creatorcontrib><title>The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>Highlights • Genistein induces ABCC1 and ABCG2 protein expression in breast cancer cell lines. • ABCG2 induction leads to enhanced chemoresistance to doxorubicin and mitoxantrone. • Transporter induction takes places at the translational level and is miRNA-mediated • The effect is independent of classical estrogen receptors.</description><subject>Antineoplastic Agents - pharmacology</subject><subject>ATP Binding Cassette Transporter, Sub-Family G, Member 2 - biosynthesis</subject><subject>ATP Binding Cassette Transporter, Sub-Family G, Member 2 - drug effects</subject><subject>ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - genetics</subject><subject>Breast Neoplasms - metabolism</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer therapies</subject><subject>Chemoresistance</subject><subject>Chemotherapy</subject><subject>Cytotoxicity</subject><subject>Disease</subject><subject>Dose-Response Relationship, Drug</subject><subject>Doxorubicin - pharmacology</subject><subject>Drug Resistance, Multiple - drug effects</subject><subject>Drug Resistance, Neoplasm - drug effects</subject><subject>Drugs</subject><subject>Estrogens</subject><subject>Female</subject><subject>Food-Drug Interactions</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genistein</subject><subject>Genistein - toxicity</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Life sciences</subject><subject>MCF-7 Cells</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Mitoxantrone - pharmacology</subject><subject>Multidrug resistance</subject><subject>Multidrug Resistance-Associated Proteins - biosynthesis</subject><subject>Multidrug Resistance-Associated Proteins - drug effects</subject><subject>Multidrug Resistance-Associated Proteins - genetics</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - drug effects</subject><subject>Neoplasm Proteins - genetics</subject><subject>Phytoestrogens - toxicity</subject><subject>Protein Biosynthesis</subject><subject>Protein Synthesis Inhibitors - pharmacology</subject><subject>Risk Assessment</subject><subject>Translational regulation</subject><subject>Tumors</subject><subject>Up-Regulation</subject><subject>Womens health</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks2O1DAMxyMEYoeFN0AoEhcuLc5394K0jPiSVuLAco7S1J3J0GmHJEWaB-C9SekC0l44RJHjn-3YfxPynEHNgOnXh9q7ccBc82LVIGqQ8IBsWGN4Za4aeEg2IEBWohHqgjxJ6QAAShr1mFxwA0JIpTfk5-0e6Wl_zhOmHKcdjrSckDKGkeK4d6PHRI_zkEMX5x2NmIpzeaUFaCO6lKlf7Eg9DgMdwlgC2jPN0Y1pcDlMoxtK3G5eDTr19PrtdvWfppgxpqfkUe-GhM_u7kvy9f272-3H6ubzh0_b65vKS6lyZRrlBW-vtOnavgfPGJema7xGD8a1TPjGad0qBc61vVONRNfz4pLQaMNRXJJXa95TnL7PpWN7DGn5thtxmpNlpYKRmglV0Jf30MM0x9LKb0orqTVjhZIr5eOUUsTenmI4uni2DOwikz3YVSa7yGRB2CJTCXtxl3xuj9j9DfqjSwHerACWafwIGG3yAcuUuxDRZ9tN4X8V7ifwRZng3fANz5j-9WITt2C_LKuybArTAjgAF78Aa728qw</recordid><startdate>20160628</startdate><enddate>20160628</enddate><creator>Rigalli, Juan Pablo</creator><creator>Tocchetti, Guillermo Nicolás</creator><creator>Arana, Maite Rocío</creator><creator>Villanueva, Silvina Stella Maris</creator><creator>Catania, Viviana Alicia</creator><creator>Theile, Dirk</creator><creator>Ruiz, María Laura</creator><creator>Weiss, Johanna</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20160628</creationdate><title>The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters</title><author>Rigalli, Juan Pablo ; Tocchetti, Guillermo Nicolás ; Arana, Maite Rocío ; Villanueva, Silvina Stella Maris ; Catania, Viviana Alicia ; Theile, Dirk ; Ruiz, María Laura ; Weiss, Johanna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-785c32b967dbff0c11247d8c6ec07ab13c8a66b550aabfa584eaf207a408672e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Antineoplastic Agents - pharmacology</topic><topic>ATP Binding Cassette Transporter, Sub-Family G, Member 2 - biosynthesis</topic><topic>ATP Binding Cassette Transporter, Sub-Family G, Member 2 - drug effects</topic><topic>ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - genetics</topic><topic>Breast Neoplasms - metabolism</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer therapies</topic><topic>Chemoresistance</topic><topic>Chemotherapy</topic><topic>Cytotoxicity</topic><topic>Disease</topic><topic>Dose-Response Relationship, Drug</topic><topic>Doxorubicin - pharmacology</topic><topic>Drug Resistance, Multiple - drug effects</topic><topic>Drug Resistance, Neoplasm - drug effects</topic><topic>Drugs</topic><topic>Estrogens</topic><topic>Female</topic><topic>Food-Drug Interactions</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genistein</topic><topic>Genistein - toxicity</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Life sciences</topic><topic>MCF-7 Cells</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Mitoxantrone - pharmacology</topic><topic>Multidrug resistance</topic><topic>Multidrug Resistance-Associated Proteins - biosynthesis</topic><topic>Multidrug Resistance-Associated Proteins - drug effects</topic><topic>Multidrug Resistance-Associated Proteins - genetics</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Proteins - drug effects</topic><topic>Neoplasm Proteins - genetics</topic><topic>Phytoestrogens - toxicity</topic><topic>Protein Biosynthesis</topic><topic>Protein Synthesis Inhibitors - pharmacology</topic><topic>Risk Assessment</topic><topic>Translational regulation</topic><topic>Tumors</topic><topic>Up-Regulation</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rigalli, Juan Pablo</creatorcontrib><creatorcontrib>Tocchetti, Guillermo Nicolás</creatorcontrib><creatorcontrib>Arana, Maite Rocío</creatorcontrib><creatorcontrib>Villanueva, Silvina Stella Maris</creatorcontrib><creatorcontrib>Catania, Viviana Alicia</creatorcontrib><creatorcontrib>Theile, Dirk</creatorcontrib><creatorcontrib>Ruiz, María Laura</creatorcontrib><creatorcontrib>Weiss, Johanna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rigalli, Juan Pablo</au><au>Tocchetti, Guillermo Nicolás</au><au>Arana, Maite Rocío</au><au>Villanueva, Silvina Stella Maris</au><au>Catania, Viviana Alicia</au><au>Theile, Dirk</au><au>Ruiz, María Laura</au><au>Weiss, Johanna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>2016-06-28</date><risdate>2016</risdate><volume>376</volume><issue>1</issue><spage>165</spage><epage>172</epage><pages>165-172</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><abstract>Highlights • Genistein induces ABCC1 and ABCG2 protein expression in breast cancer cell lines. • ABCG2 induction leads to enhanced chemoresistance to doxorubicin and mitoxantrone. • Transporter induction takes places at the translational level and is miRNA-mediated • The effect is independent of classical estrogen receptors.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>27033456</pmid><doi>10.1016/j.canlet.2016.03.040</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 2016-06, Vol.376 (1), p.165-172 |
| issn | 0304-3835 1872-7980 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1785746135 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Antineoplastic Agents - pharmacology ATP Binding Cassette Transporter, Sub-Family G, Member 2 - biosynthesis ATP Binding Cassette Transporter, Sub-Family G, Member 2 - drug effects ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer therapies Chemoresistance Chemotherapy Cytotoxicity Disease Dose-Response Relationship, Drug Doxorubicin - pharmacology Drug Resistance, Multiple - drug effects Drug Resistance, Neoplasm - drug effects Drugs Estrogens Female Food-Drug Interactions Gene Expression Regulation, Neoplastic Genistein Genistein - toxicity Hematology, Oncology and Palliative Medicine Humans Life sciences MCF-7 Cells MicroRNAs - genetics MicroRNAs - metabolism Mitoxantrone - pharmacology Multidrug resistance Multidrug Resistance-Associated Proteins - biosynthesis Multidrug Resistance-Associated Proteins - drug effects Multidrug Resistance-Associated Proteins - genetics Neoplasm Proteins - biosynthesis Neoplasm Proteins - drug effects Neoplasm Proteins - genetics Phytoestrogens - toxicity Protein Biosynthesis Protein Synthesis Inhibitors - pharmacology Risk Assessment Translational regulation Tumors Up-Regulation Womens health |
| title | The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T16%3A40%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20phytoestrogen%20genistein%20enhances%20multidrug%20resistance%20in%20breast%20cancer%20cell%20lines%20by%20translational%20regulation%20of%20ABC%20transporters&rft.jtitle=Cancer%20letters&rft.au=Rigalli,%20Juan%20Pablo&rft.date=2016-06-28&rft.volume=376&rft.issue=1&rft.spage=165&rft.epage=172&rft.pages=165-172&rft.issn=0304-3835&rft.eissn=1872-7980&rft_id=info:doi/10.1016/j.canlet.2016.03.040&rft_dat=%3Cproquest_cross%3E4043852541%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1786546611&rft_id=info:pmid/27033456&rft_els_id=1_s2_0_S0304383516302002&rfr_iscdi=true |