The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters

Highlights • Genistein induces ABCC1 and ABCG2 protein expression in breast cancer cell lines. • ABCG2 induction leads to enhanced chemoresistance to doxorubicin and mitoxantrone. • Transporter induction takes places at the translational level and is miRNA-mediated • The effect is independent of cla...

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Veröffentlicht in:	Cancer letters 2016-06, Vol.376 (1), p.165-172
Hauptverfasser:	Rigalli, Juan Pablo, Tocchetti, Guillermo Nicolás, Arana, Maite Rocío, Villanueva, Silvina Stella Maris, Catania, Viviana Alicia, Theile, Dirk, Ruiz, María Laura, Weiss, Johanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology ATP Binding Cassette Transporter, Sub-Family G, Member 2 - biosynthesis ATP Binding Cassette Transporter, Sub-Family G, Member 2 - drug effects ATP Binding Cassette Transporter, Sub-Family G, Member 2 - genetics Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer therapies Chemoresistance Chemotherapy Cytotoxicity Disease Dose-Response Relationship, Drug Doxorubicin - pharmacology Drug Resistance, Multiple - drug effects Drug Resistance, Neoplasm - drug effects Drugs Estrogens Female Food-Drug Interactions Gene Expression Regulation, Neoplastic Genistein Genistein - toxicity Hematology, Oncology and Palliative Medicine Humans Life sciences MCF-7 Cells MicroRNAs - genetics MicroRNAs - metabolism Mitoxantrone - pharmacology Multidrug resistance Multidrug Resistance-Associated Proteins - biosynthesis Multidrug Resistance-Associated Proteins - drug effects Multidrug Resistance-Associated Proteins - genetics Neoplasm Proteins - biosynthesis Neoplasm Proteins - drug effects Neoplasm Proteins - genetics Phytoestrogens - toxicity Protein Biosynthesis Protein Synthesis Inhibitors - pharmacology Risk Assessment Translational regulation Tumors Up-Regulation Womens health
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Beschreibung
Zusammenfassung:	Highlights • Genistein induces ABCC1 and ABCG2 protein expression in breast cancer cell lines. • ABCG2 induction leads to enhanced chemoresistance to doxorubicin and mitoxantrone. • Transporter induction takes places at the translational level and is miRNA-mediated • The effect is independent of classical estrogen receptors.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.03.040