Syndecan-1, Epithelial-Mesenchymal Transition Markers (E-cadherin/β-catenin) and Neoangiogenesis-related Proteins (PCAM-1 and Endoglin) in Colorectal Cancer

Syndecan-1, Epithelial-Mesenchymal Transition Markers (E-cadherin/β-catenin) and Neoangiogenesis-related Proteins (PCAM-1 and Endoglin) in Colorectal Cancer

The Syndecan-1 protein plays a crucial role in cell proliferation, cell adhesion, cell migration and angiogenesis and, at the same time, its co-expression with E-cadherin is regulated during epithelial-mesenchymal transition (EMT). In colorectal cancer (CRC), the expression of syndecan-1, E-cadherin...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Anticancer research 2016-05, Vol.36 (5), p.2271-2280
Hauptverfasser: Mitselou, Antigony, Galani, Vassiliki, Skoufi, Urania, Arvanitis, Dimitris L, Lampri, Evangeli, Ioachim, Elli
Format: Artikel
Sprache:eng
Schlagworte:
Adenocarcinoma - chemistry
Adenocarcinoma - mortality
Adenocarcinoma, Mucinous - chemistry
Adenocarcinoma, Mucinous - mortality
Adult
Aged
Aged, 80 and over
beta Catenin - analysis
Cadherins - analysis
Carcinoma - chemistry
Carcinoma - mortality
Cell Differentiation
Colorectal Neoplasms - chemistry
Colorectal Neoplasms - mortality
Endoglin - analysis
Epithelial Cells - chemistry
Epithelial-Mesenchymal Transition
Female
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Proteins - analysis
Neovascularization, Pathologic - metabolism
Platelet Endothelial Cell Adhesion Molecule-1 - analysis
Syndecan-1 - analysis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The Syndecan-1 protein plays a crucial role in cell proliferation, cell adhesion, cell migration and angiogenesis and, at the same time, its co-expression with E-cadherin is regulated during epithelial-mesenchymal transition (EMT). In colorectal cancer (CRC), the expression of syndecan-1, E-cadherin/β-catenin complex is frequently disturbed. Angiogenesis is critical for the growth and metastatic spread of tumors. In the present study, we focused on the expression of these biological molecules and their prognostic significance in human CRC. Formalin-fixed paraffin-embedded surgical specimens from 69 patients with CRC were immunostained for syndecan-1, E-cadherin, β-catenin, endoglin (CD105) and CD31 (platelet cell adhesion molecule (PCAM-1)). A significant association was found between syndecan-1 with E-cadherin (p
ISSN:1791-7530