Polyomavirus Small t Antigen Prevents Retinoic Acid-Induced Retinoblastoma Protein Hypophosphorylation and Redirects Retinoic Acid-Induced G sub(0) Arrest and Differentiation to Apoptosis

Polyomavirus small t antigen (ST) impedes late features of retinoic acid (RA)-induced HL-60 myeloid differentiation as well as growth arrest, causing apoptosis instead. HL-60 cells were stably transfected with ST. ST slowed the cell cycle, retarding G sub(2)/M in particular. Treated with RA, the ST...

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Veröffentlicht in:	Journal of virology 2001-06, Vol.75 (11), p.5302-5314
Hauptverfasser:	Yen, A, Placanica, L, Bloom, S, Varvayanis, S
Format:	Artikel
Sprache:	eng
Schlagworte:	cell cycle arrest polyomavirus RB protein tumor suppressors
Online-Zugang:	Volltext
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