Effect of Afobazole and Betaine on DNA Damage in Placental and Embryonic Tissues of Rats with Experimental Streptozocin Diabetes

DNA comet assay showed that the level of DNA damage in the placental and embryonic tissues of rats with streptozotocin-induced diabetes mellitus increased on gestation days 14 and 20. Afobazole and betaine administered per os effectively decreased the level of genotoxic damage; afobazole was most ef...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2015-10, Vol.159 (6), p.757-760
Hauptverfasser:	Zabrodina, V. V., Shreder, E. D., Shreder, O. V., Durnev, A. D., Seredenin, S. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimutagenic Agents - pharmacology Benzimidazoles - pharmacology Betaine - pharmacology Biomedical and Life Sciences Biomedicine Cell Biology Diabetes mellitus Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes, Gestational - genetics Diabetes, Gestational - metabolism Diabetes, Gestational - pathology DNA DNA damage DNA Damage - drug effects Embryo, Mammalian - cytology Embryo, Mammalian - drug effects Embryo, Mammalian - metabolism Embryonic Development - drug effects Female Genetic research Internal Medicine Laboratory Medicine Morpholines - pharmacology Pathology Placenta - drug effects Placenta - metabolism Pregnancy Rats Streptozocin
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Beschreibung
Zusammenfassung:	DNA comet assay showed that the level of DNA damage in the placental and embryonic tissues of rats with streptozotocin-induced diabetes mellitus increased on gestation days 14 and 20. Afobazole and betaine administered per os effectively decreased the level of genotoxic damage; afobazole was most efficient in doses of 10 and 50 mg/kg and betaine in a dose of 100 mg/kg.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-015-3068-5