Stochastic resonance in the synaptic transmission between hair cells and vestibular primary afferents in development

Highlights • We show that the peripheral vestibular system in development exhibits stochastic resonance. • Blockage of the synaptic transmission with selective antagonists abolished the stochastic resonance. • Simulations on a model of the hair cell – primary afferent synapse qualitatively reproduce...

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Veröffentlicht in:	Neuroscience 2016-05, Vol.322, p.416-429
Hauptverfasser:	Flores, A, Manilla, S, Huidobro, N, De la Torre-Valdovinos, B, Kristeva, R, Mendez-Balbuena, I, Galindo, F, Treviño, M, Manjarrez, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chickens Cochlear Nerve - drug effects Cochlear Nerve - growth & development Cochlear Nerve - physiology Computer Simulation development Hair Cells, Vestibular - drug effects Hair Cells, Vestibular - physiology Hearing - drug effects Hearing - physiology inner ear mechanoreceptor Models, Neurological Neurology noise Physical Stimulation primary afferents Rana catesbeiana Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - metabolism Receptors, Kainic Acid - antagonists & inhibitors Receptors, Kainic Acid - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - metabolism Semicircular Canals - drug effects Semicircular Canals - growth & development Semicircular Canals - physiology Stochastic Processes Synaptic Transmission - drug effects Synaptic Transmission - physiology vestibular
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Zusammenfassung:	Highlights • We show that the peripheral vestibular system in development exhibits stochastic resonance. • Blockage of the synaptic transmission with selective antagonists abolished the stochastic resonance. • Simulations on a model of the hair cell – primary afferent synapse qualitatively reproduced the stochastic resonance behavior.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.02.051