Systemic administration of vitamins C and E attenuates nociception induced by chronic constriction injury of the sciatic nerve in rats

Highlights • Vitamin C and E increase thermal and mechanical thresholds in CCI rats. • Antinociceptive effect of vitamin C and E and vitamin C + E in CCI rats. • Vitamin C and E and vitamin C + E ameliorate sciatic functional index in CCI rats. • Highest antinociception with co-administration of vit...

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Veröffentlicht in:	Brain research bulletin 2016-03, Vol.121, p.169-177
Hauptverfasser:	Riffel, Ana Paula K, de Souza, Jéssica A, Santos, Maria do Carmo Q, Horst, Andréa, Scheid, Taína, Kolberg, Carolina, Belló-Klein, Adriane, Partata, Wania A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Transaminase - metabolism Analgesics - therapeutic use Analysis of Variance Animals Antioxidant Antioxidants - metabolism Ascorbic Acid - administration & dosage Aspartate Aminotransferases - metabolism Constriction Disease Models, Animal gamma-Glutamyltransferase - metabolism Hyperalgesia - drug therapy Hyperalgesia - physiopathology Lipid peroxidation Locomotion - drug effects Male Mechanical threshold Neurology Nociception - drug effects Oxidative stress Pain Measurement Pain Threshold - drug effects Physical Stimulation - adverse effects Rats Rats, Wistar Sciatic functional index Sciatica - drug therapy Sciatica - etiology Thermal threshold Time Factors Vitamin E - administration & dosage
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Zusammenfassung:	Highlights • Vitamin C and E increase thermal and mechanical thresholds in CCI rats. • Antinociceptive effect of vitamin C and E and vitamin C + E in CCI rats. • Vitamin C and E and vitamin C + E ameliorate sciatic functional index in CCI rats. • Highest antinociception with co-administration of vitamin C + E and gabapentin.
ISSN:	0361-9230 1873-2747
DOI:	10.1016/j.brainresbull.2016.02.004