Green tea compound epigallo-catechin-3-gallate (EGCG) increases neuronal survival in adult hippocampal neurogenesis in vivo and in vitro

Highlights • EGCG favors the survival of newborn neurons in the hippocampus. • EGCG is proneurogenic upon adult hippocampal precursor cells in culture. • EGCG might act through phospho-Akt.

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Veröffentlicht in:	Neuroscience 2016-05, Vol.322, p.208-220
Hauptverfasser:	Ortiz-López, L, Márquez-Valadez, B, Gómez-Sánchez, A, Silva-Lucero, M.D.C, Torres-Pérez, M, Téllez-Ballesteros, R.I, Ichwan, M, Meraz-Ríos, M.A, Kempermann, G, Ramírez-Rodríguez, G.B
Format:	Artikel
Sprache:	eng
Schlagworte:	adult neurogenesis Animals Camellia sinensis Catechin - analogs & derivatives Catechin - chemistry Catechin - pharmacology Cell Survival - drug effects Cell Survival - physiology Cells, Cultured Dose-Response Relationship, Drug EGCG hippocampus Hippocampus - drug effects Hippocampus - physiology Male Mice, Inbred BALB C Microtubule-Associated Proteins - metabolism Neural Stem Cells - drug effects Neural Stem Cells - physiology Neurogenesis - drug effects Neurogenesis - physiology Neurology Neurons - drug effects Neurons - physiology Neuropeptides - metabolism Neuroprotective Agents - chemistry Neuroprotective Agents - pharmacology nutrition Phosphatidylinositol 3-Kinases - metabolism PI3K-Akt Proto-Oncogene Proteins c-akt - metabolism survival Tea - chemistry
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Beschreibung
Zusammenfassung:	Highlights • EGCG favors the survival of newborn neurons in the hippocampus. • EGCG is proneurogenic upon adult hippocampal precursor cells in culture. • EGCG might act through phospho-Akt.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2016.02.040