Suppressor of cytokine signaling 2 modulates the immune response profile and development of experimental cerebral malaria

Highlights • Plasmodium berghei ANKA (PbA) infection decreases SOCS2 expression in brain. • SOCS2 orchestrates immune response and neuroinflammation during PbA infection. • Neurotrophic factors production is modulated by SOCS2. • SOCS2 control anxiety-related behaviour and cognitive decline during P...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2016-05, Vol.54, p.73-85
Hauptverfasser:	Brant, Fatima, Miranda, Aline S, Esper, Lisia, Gualdrón-López, Melisa, Cisalpino, Daniel, de Souza, Danielle da Gloria, Rachid, Milene Alvarenga, Tanowitz, Herbert B, Teixeira, Mauro Martins, Teixeira, Antônio Lucio, Machado, Fabiana Simão
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals BDNF Brain - metabolism Brain-Derived Neurotrophic Factor - metabolism Cerebral malaria Cytokines - metabolism Disease Models, Animal Female GDNF Immune regulation l-NAME Malaria, Cerebral - immunology Malaria, Cerebral - metabolism Malaria, Cerebral - parasitology Malaria, Cerebral - therapy Mice Mice, Inbred C57BL Mice, Knockout Nerve Growth Factors - metabolism Neuroimmune response Neuroinflammation Neurotrophic factors Nitric oxide Plasmodium berghei Plasmodium berghei - isolation & purification Plasmodium falciparum Psychiatry SOCS2 Spleen - metabolism Suppressor of Cytokine Signaling Proteins - antagonists & inhibitors Suppressor of Cytokine Signaling Proteins - deficiency Suppressor of Cytokine Signaling Proteins - immunology Suppressor of Cytokine Signaling Proteins - metabolism T-Lymphocytes, Regulatory - metabolism Th17 Cells - metabolism Transforming Growth Factor beta - metabolism
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Zusammenfassung:	Highlights • Plasmodium berghei ANKA (PbA) infection decreases SOCS2 expression in brain. • SOCS2 orchestrates immune response and neuroinflammation during PbA infection. • Neurotrophic factors production is modulated by SOCS2. • SOCS2 control anxiety-related behaviour and cognitive decline during PbA infection. • Interrelation of SOCS2/NO in the orquestration of immune response and CM outcome.
ISSN:	0889-1591 1090-2139
DOI:	10.1016/j.bbi.2016.01.002