Functional Activity of Th-17 Lymphocytes in Pulmonary Tuberculosis

Increased content of CD4 + CD161 + IL-17A + Th17 lymphocytes in the peripheral blood was found in patients with pulmonary tuberculosis irrespective of the clinical form (infiltrative, disseminated) and variant of the disease (drug-sensitive, drug-resistant). The elevated content of Th17 cells in pul...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2014-04, Vol.156 (6), p.743-745
Hauptverfasser:	Kononova, T. E., Urazova, O. I., Novitskii, V. V., Churina, E. G., Kolobovnikova, Yu. V., Ignatov, M. V., Zakharova, P. A., Pechenova, O. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomedical and Life Sciences Biomedicine CD4 Antigens - metabolism Cell Biology Cells, Cultured Female Humans Interleukin-17 - metabolism Interleukin-22 Interleukins - metabolism Internal Medicine Laboratory Medicine Lymphocytes Male Middle Aged Mycobacterium Mycobacterium tuberculosis - immunology NK Cell Lectin-Like Receptor Subfamily B - metabolism Pathology Pulmonary tuberculosis Th17 Cells - immunology Tuberculosis, Pulmonary - immunology Young Adult
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Zusammenfassung:	Increased content of CD4 + CD161 + IL-17A + Th17 lymphocytes in the peripheral blood was found in patients with pulmonary tuberculosis irrespective of the clinical form (infiltrative, disseminated) and variant of the disease (drug-sensitive, drug-resistant). The elevated content of Th17 cells in pulmonary tuberculosis is associated with hypersecretion of Th17-associated cytokines IL-17A and IL-22 in vitro that was most pronounced (in case of IL-17A) in patients with disseminated pulmonary tuberculosis.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-014-2438-8