In vitro anticancer properties and biological evaluation of novel natural alkaloid jerantinine B

Highlights • Natural product indole alkaloid. • Anticancer activity. • Elucidation of mechanisms of action: Microtubule disrupting agent; inhibitor of PLK1; generation of reactive oxygen species.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2016-01, Vol.370 (2), p.185-197
Hauptverfasser:	Qazzaz, Mohannad E, Raja, Vijay J, Lim, Kuan-Hon, Kam, Toh-Seok, Lee, Jong Bong, Gershkovich, Pavel, Bradshaw, Tracey D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Apoptosis Apoptosis - drug effects Bioavailability Cancer Cell culture Cell cycle Cell Cycle Checkpoints - drug effects Cell Cycle Proteins - antagonists & inhibitors Cell Line, Tumor Colon Cytoskeleton - drug effects Drug dosages Hematology, Oncology and Palliative Medicine Humans Indole Alkaloids - pharmacology Kinases Natural products PLK1 Polo-Like Kinase 1 Protein Serine-Threonine Kinases - antagonists & inhibitors Proto-Oncogene Proteins - antagonists & inhibitors Reactive oxygen species Reactive Oxygen Species - metabolism Software Tabernaemontana Tubulin Vincristine - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Natural product indole alkaloid. • Anticancer activity. • Elucidation of mechanisms of action: Microtubule disrupting agent; inhibitor of PLK1; generation of reactive oxygen species.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2015.10.013