Astrocytic vesicles and gliotransmitters: Slowness of vesicular release and synaptobrevin2-laden vesicle nanoarchitecture
Highlights • Unlike neurons, astrocytic vesicles have one third of synaptobrevin 2 (Sb2) molecules in a vesicle. • The paucity of Sb2 in astrocytes may determine the slow secretory profile. • Distinct mobility of glutamatergic vs. peptidergic vesicles contributes to astrocytic plasticity.
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| Veröffentlicht in: | Neuroscience 2016-05, Vol.323, p.67-75 |
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| container_title | Neuroscience |
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| creator | Zorec, R Verkhratsky, A Rodríguez, J.J Parpura, V |
| description | Highlights • Unlike neurons, astrocytic vesicles have one third of synaptobrevin 2 (Sb2) molecules in a vesicle. • The paucity of Sb2 in astrocytes may determine the slow secretory profile. • Distinct mobility of glutamatergic vs. peptidergic vesicles contributes to astrocytic plasticity. |
| doi_str_mv | 10.1016/j.neuroscience.2015.02.033 |
| format | Article |
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| ispartof | Neuroscience, 2016-05, Vol.323, p.67-75 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals astrocytes Astrocytes - metabolism Astrocytes - ultrastructure ATP exocytosis Exocytosis - physiology gliotransmission glutamate Humans Membrane Transport Proteins - metabolism Neurology Synaptic Vesicles - metabolism Synaptic Vesicles - ultrastructure Vesicle-Associated Membrane Protein 2 - metabolism vesicles |
| title | Astrocytic vesicles and gliotransmitters: Slowness of vesicular release and synaptobrevin2-laden vesicle nanoarchitecture |
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