Astrocytic vesicles and gliotransmitters: Slowness of vesicular release and synaptobrevin2-laden vesicle nanoarchitecture

Highlights • Unlike neurons, astrocytic vesicles have one third of synaptobrevin 2 (Sb2) molecules in a vesicle. • The paucity of Sb2 in astrocytes may determine the slow secretory profile. • Distinct mobility of glutamatergic vs. peptidergic vesicles contributes to astrocytic plasticity.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience 2016-05, Vol.323, p.67-75
Hauptverfasser:	Zorec, R, Verkhratsky, A, Rodríguez, J.J, Parpura, V
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals astrocytes Astrocytes - metabolism Astrocytes - ultrastructure ATP exocytosis Exocytosis - physiology gliotransmission glutamate Humans Membrane Transport Proteins - metabolism Neurology Synaptic Vesicles - metabolism Synaptic Vesicles - ultrastructure Vesicle-Associated Membrane Protein 2 - metabolism vesicles
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Unlike neurons, astrocytic vesicles have one third of synaptobrevin 2 (Sb2) molecules in a vesicle. • The paucity of Sb2 in astrocytes may determine the slow secretory profile. • Distinct mobility of glutamatergic vs. peptidergic vesicles contributes to astrocytic plasticity.
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2015.02.033